ACEP ID:

Endotracheal Intubation

Critical Issues in the Management of Adult Patients Requiring Endotracheal Intubation in the Emergency Department

Scope of Application

This guideline is intended for physicians working in emergency departments (EDs).

Inclusion Criteria

This guideline is intended for adult patients aged 18 years and older presenting to the ED who require endotracheal intubation.

Exclusion Criteria

This guideline is not intended for pediatric patients or patients undergoing emergent fiberoptic intubation.


Recommendations offered in this policy are not intended to represent the only diagnostic and management options that the emergency physician should consider. ACEP recognizes the importance of the individual physician’s judgment and patient preferences.

Critical Questions

  • For adult patients presenting to the ED requiring endotracheal intubation, are there periprocedural interventions that can reduce the incidence of periintubation hypoxemia?

    Recommendations
    Level A Recommendations

    None specified.

    Level B Recommendations

    When feasible, optimize preoxygenation using noninvasive ventilation (NIV)* over conventional oxygen therapy (COT) for patients being intubated in the ED.

    Level C Recommendations

    When NIV is not feasible, consider using high-flow nasal cannula (HFNC) for preoxygenation of hypoxemic patients being intubated in the ED.

    Consider video laryngoscopy (VL) when available for patients being intubated in the ED.

    Consider using apneic oxygenation (AO) for patients being intubated in the ED. (Consensus)

    *Relative contraindications to the use of NIV include patients with increased aspiration risk due to symptoms such as vomiting or decrease level of consciousness and noncompliance due to increased agitation.

    Level A Recommendations

    None specified.

    Level B Recommendations

    When feasible, optimize preoxygenation using noninvasive ventilation (NIV)* over conventional oxygen therapy (COT) for patients being intubated in the ED.

    Level C Recommendations

    When NIV is not feasible, consider using high-flow nasal cannula (HFNC) for preoxygenation of hypoxemic patients being intubated in the ED.

    Consider video laryngoscopy (VL) when available for patients being intubated in the ED.

    Consider using apneic oxygenation (AO) for patients being intubated in the ED. (Consensus)

    *Relative contraindications to the use of NIV include patients with increased aspiration risk due to symptoms such as vomiting or decrease level of consciousness and noncompliance due to increased agitation.

  • For adult patients presenting to the ED requiring endotracheal intubation, are there periprocedural interventions that can reduce the incidence of peri-intubation hypotension?

    Recommendations
    Level A Recommendations

    None specified.

    Level B Recommendations

    Use etomidate or ketamine as an induction agent to reduce the risk of peri-intubation hypotension in patients requiring endotracheal intubation in the ED.

    Level C Recommendations

    Avoid the use of fentanyl, midazolam, or propofol as an induction or coinduction agent in patients requiring endotracheal intubation in the ED who are at increased risk for postintubation hypotension.

    Level A Recommendations

    None specified.

    Level B Recommendations

    Use etomidate or ketamine as an induction agent to reduce the risk of peri-intubation hypotension in patients requiring endotracheal intubation in the ED.

    Level C Recommendations

    Avoid the use of fentanyl, midazolam, or propofol as an induction or coinduction agent in patients requiring endotracheal intubation in the ED who are at increased risk for postintubation hypotension.

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Findings and Strength of Recommendations

Clinical findings and strength of recommendations regarding patient management were made according to the following criteria:
Level A recommendations
Generally accepted principles for patient care that reflect a high degree of clinical certainty (eg, based on evidence from 1 or more Class of Evidence I or multiple Class of Evidence II studies).
Level B recommendations
Recommendations for patient care that may identify a particular strategy or range of strategies that reflect moderate clinical certainty (eg, based on evidence from 1 or more Class of Evidence II studies or strong consensus of Class of Evidence III studies).
Level C recommendations
Recommendations for patient care that are based on evidence from Class of Evidence III studies or, in the absence of adequate published literature, based on expert consensus. In instances in which consensus recommendations are made, “consensus” is placed in parentheses at the end of the recommendation.
There are certain circumstances in which the recommendations stemming from a body of evidence should not be rated as highly as the individual studies on which they are based. Factors such as heterogeneity of results, uncertainty about effect magnitude, and publication bias, among others, might lead to a downgrading of recommendations.
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