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Management (CDC Interim Guidance)

If monkeypox is confirmed, health departments can order medical countermeasures (antivirals and vaccine) from the Strategic National Stockpile upon receipt of a positive orthopoxvirus test.

Many individuals infected with monkeypox virus have a mild, self-limiting disease course lasting from 2 to 4 weeks in the absence of specific therapy.

However, the prognosis for monkeypox depends on multiple factors such as previous vaccination status, initial health status, concurrent illnesses, and comorbidities among others.

Persons who should be considered for treatment following consultation with CDC might include:

  • Persons with severe disease (e.g., hemorrhagic disease, confluent lesions, sepsis, encephalitis, or other conditions requiring hospitalization)
  • Persons who may be at high risk of severe disease:
    • Persons with immunocompromise (e.g., human immunodeficiency virus/acquired immune deficiency syndrome infection, leukemia, lymphoma, generalized malignancy, solid organ transplantation, therapy with alkylating agents, antimetabolites, radiation, tumor necrosis factor inhibitors, high-dose corticosteroids, being a recipient with hematopoietic stem cell transplant <24 months post-transplant or ≥24 months but with graft-versus-host disease or disease relapse, or having autoimmune disease with immunodeficiency as a clinical component)
    • Pediatric populations, particularly patients younger than 8 years of age
    • Pregnant or breastfeeding women
    • Persons with one or more complications (e.g., secondary bacterial skin infection; gastroenteritis with severe nausea/vomiting, diarrhea, or dehydration; bronchopneumonia; concurrent disease or other comorbidities)
  • Persons with monkeypox virus aberrant infections that include its accidental implantation in eyes, mouth, or other anatomical areas where monkeypox virus infection might constitute a special hazard (e.g., the genitals or anus).

Duration of Isolation Procedures

The American College of Emergency Physicians Guide to Monkey Pox.

Orthopoxvirus Vaccine Guidance for Persons at Risk for Occupational Exposure

The American College of Emergency Physicians Guide to Monkey Pox.

Monitoring Exposed Healthcare Professionals

The American College of Emergency Physicians Guide to Monkey Pox.

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